In 2010 the independent research network Cochrane Collaboration performed a meta-analysis on the effect on adherence compounds in embryo transfer media. The results show that EmbryoGlue, with the adherence compound hyaluronic acid together with recombinant albumin gave an increased pregnancy rate of 8%, compared to transfer media with low or no hyaluronic acid. Concept uses embryo glue for all embryo transfers without extra costs to the patient.
The 2010 meta-analysis has now been updated with more studies. The results confirm previous findings and show that EmbryoGlue also increases take-home baby rate of 8% compared to a transfer medium with low or no hyaluronic acid.
Important notes on the Embryoscope time-lapse incubator
What is the embryoscope?
The embryoscope is an embryo culture incubator that contains a time-lapse camera.
How does it work?
The camera takes photos of the embryos as they grow and develop. The images obtained are then used to help the embryologist choose an embryo to transfer during IVF/ICSI treatment.
Will the embryoscope improve the quality of the embryos?
No. The embryoscope is a tool that helps the embryologist choose an embryo to transfer rather than improving the quality of the embryo.
Will the embryoscope identify embryos with the correct number of chromosomes?
No. At present the most definitive way to screen embryos for the correct number of chromosomes is through Preimplantation Genetic Screening using array comparative genomic hybridization (aCGH). It is well accepted that some embryos with a “good grade” don’t have the appropriate number of chromosomes so a lot more research is required to see if the information gained from the embryoscope is related to the number of chromosomes an embryo has.
More research is required before the embryoscope can be considered for routine clinical application.
Please note: Concept does not use Embryoscopes
Chromosome screening of embryos in IVF
The laboratory at Concept Fertility Centre has set up a new test called 24sure that enables scientists to screen developing embryos during IVF and confirm that the correct number of all the chromosomes are present in each embryo. There is growing evidence that a major factor in the failure to establish or maintain a pregnancy is when the cells in the embryo contain the wrong number of chromosomes, a condition termed aneuploidy. It has been known for some time that a significant number of human embryos have the wrong number of chromosomes. It is normal for a cell to contain 22 pairs of chromosomes plus the sex chromosomes, either XX for females or XY for males.
Problems such as reduced embryo development or miscarriage can arise when the embryo's cells contain too many or too few chromosomes. Many fertility doctors believe this new testing should increase the likelihood of an embryo transferred during IVF treatment resulting in a successful healthy pregnancy. Read more.